By Dario Roccatello, Lorenzo Emmi
In this quantity dedicated to systemic lupus erythematosus (SLE) and Sjögren syndrome, best experts from various disciplines current the newest examine findings on many elements of the ailments and describe the newest traits in therapy, reminiscent of the “treat to focus on” procedure. either uncomplicated technology and medical medication are addressed, with emphasis at the so much promising scientific and laboratory-based reports. The assurance is accomplished in scope, encompassing, for instance, epidemiology, pathogenesis, autoantibodies and biomarkers, sickness manifestations, involvement of alternative organs or structures, relationships with different issues, organic treatment of SLE, and systemic therapy of Sjögren syndrome. Readers will locate this primary quantity of Connective Tissue ailment to be a superb resource of knowledge at the present realizing of, and medical method of, SLE and Sjögren syndrome that sincerely conveys the development made in contemporary years.
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During this quantity dedicated to systemic lupus erythematosus (SLE) and Sjögren syndrome, major experts from diversified disciplines current the newest examine findings on many facets of the ailments and describe the newest developments in remedy, resembling the “treat to focus on” strategy. either easy technology and scientific medication are addressed, with emphasis at the such a lot promising scientific and laboratory-based stories.
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Extra info for Connective Tissue Disease: A Comprehensive Guide - Volume 1
1007/978-3-319-24535-5_4 35 S. J. Cuadrado 36 that assessment of patients with SLE cannot be accomplished with a single index. Formal evaluation of three aspects of the disease, disease activity, disease damage, and patient-related quality of life is required. No data are available in the literature to suggest an optimal frequency of clinical and laboratory assessment in patients with SLE. The European League Against Rheumatism (EULAR) made some recommendations for monitoring patients with SLE in clinical practice and in observational studies [1, 2].
Hudson CA, Cao L, Kasten-Jolly J, Kirkwood JN, Lawrence DA (2003) Susceptibility of lupus-prone NZM mouse strains to lead exacerbation of systemic lupus erythematosus symptoms. J Toxicol Environ Health A 66(10):895–918 12. Hughes GC, Clark EA (2007) Regulation of dendritic cells by female sex steroids: relevance to immunity and autoimmunity. Autoimmunity 40(6):470–481 3 SLE Pathogenesis: From Apoptosis to Lymphocyte Activation 33 13. Tayel SS, Helmy AA, Ahmed R, Esmat G, Hamdi N, Abdelaziz AI (2013) Progesterone suppresses interferon signaling by repressing TLR-7 and MxA expression in peripheral blood mononuclear cells of patients infected with hepatitis C virus.
Increased levels of IFN-alpha triggered by pDCs have been demonstrated in skin specimens of SLE patients after ultraviolet exposure. Similarly, the production of other inflammatory cytokines, such as IL-1, IL-6, and TNF-alpha, by keratinocytes and lymphocytes has been shown to be influenced by UV . The role of vitamin D on the immune system has also been profoundly investigated, since insufficient circulating levels are often detected in patients with several autoimmune diseases, especially with SLE.