A 10-point circle is associated with any general point of by Ternullo M.

By Ternullo M.

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Rheological behavior, which is a property of major importance in liquid systems. At low concentration and fairly regular particles, the behavior is Newtonian, similar to the corresponding continuous phase. It means that the required force to maintain flow is proportional to the shear rate, with the viscosity as the proportionality constant. In other words, the viscosity is a measure of the resistance of a fluid to flow. Presence of particles influences viscosity in direct relation to their concentration.

Check the feasibility to form crystals of the desired product. g. pharmaceuticals) this is not the case. An important aspect is the possibility to form different polymorphs [22]. Note that the metastable form is often formed first during crystallization. Especially for pharmaceuticals extensive screening is required for application, registration and IP purposes, but for other products limited screenings are still needed in order to identify bottlenecks in the process development. 2. Once crystals have been prepared, a first idea is obtained of the possible crystal shape of the final product.

They are cohesive already in fairly loose packing, since the inter-particle forces are large in comparison to particle mass and, thus, dominate in the behavior. g. occurs during storage), when inter-particle distances are decreased. Presence of small amounts of water in a powder enhances this phenomenon of cohesivity. Several performance quality aspects of products, for example cohesivity, flowability, rheological behavior, shear strength and taste, can be measured more or less directly through standardized measurement methods (see further Chaps.

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